Besides their central role in the regulation of fluid/electrolyte balance, vascular tone and cardiac remodelling [2], the amino terminals of both atrial natriuretic peptide (ANP; NT-proANP) and brain natriuretic peptide (BNP; NT-proBNP) are elevated in septic patients, most probably due to depressed myocardial function and ventricular dilatation, which represent septic heart failure (HF) signalling. The gene discussed is NPPB; the disease is Ventriculomegaly.