SUMO3 and ovarian cancer: Western blot analysis revealed that miR-509-3p overexpression significantly reduced the expression of SUMO-3 in A2780CP70 and OVCAR-8 ovarian cancer cells (Fig. 5B, upper panel), whereas miR-509-3p inhibitors noticeably increased the expression of SUMO3 in A2780 and OVCAR-3 cells (Fig. 5B, lower panel).