Then, the aforementioned factors have also the potential of creating an appropriate microenvironment for tumor growth through the release of hormonal mediators (i.e., catecholamines, prostaglandins), cytokines (e.g., interleukin-6, IL-4 and IL-10, TGF-β) and the upregulated expression of the transcription factor hypoxia-inducible factor 1-alpha (i.e., HIF1A) with consequent enhancement of angiogenesis pathways, cell proliferation, and the metastatic ability of cancer cells [6–8]. This evidence concerns the gene HIF1A and neoplasm.