In this study, Ri. transplantation obviously ameliorated the high levels of Kyn that were induced by CRS, and apart from blocking IDO1 expression in the brain, decreased LAT1 expression levels mediated by Ri. may also exert pivotal functions in reduction of Kyn in the brain, thereby, ameliorating the levels of the toxic metabolites. The gene discussed is IDO1; the disease is congenital rubella syndrome.