As depicted in Fig. 11E, CRS led to significantly decreased mRNA expression of ISCs, while Ri. intervention resulted in a pronounced elevation of MSI1 expression and slightly increased LGR5, BMI1, and HOPX levels, suggesting a favorable resolution of Ri. colonization in the colon and fewer effects on the neogenesis of colonic epithelial cells. The gene discussed is MSI1; the disease is congenital rubella syndrome.