EZH2 and cancer: A study by Peng et al. [83] revealed that cancer epigenetic silencing consisting of enhancer of zeste homolog 2 (EZH2)-mediated histone modifications and DNA methyltransferase (DNMT) -mediated DNA methylation of the gene encoding the T helper 1-type chemokines, CXCL9 and CXCL10, decreased T cells homing and infiltration, thus potentially impairing the efficacy of immunotherapy.