Myelin associated oligodendrocyte protein (MOBP) gene has been associated with disease risk in several neurodegenerative diseases, including PSP [19, 41, 88], CBD [54], AD APOE-ε4 carriers [59], ALS [85] and PD [95], and has also been reported to be associated with white matter degradation and increased rates of decline in executive function in behavioural variant frontotemporal dementia [46]. The gene discussed is APOE; the disease is Alzheimer disease.