CEACAM5 and colorectal carcinoma: The expression of EV-delivered miR-185-5p was significantly upregulated in early-mid stage and advanced CRC groups vs. AA group (Fig. 2E); therefore, we further evaluated whether miR-185-5p was a more beneficial biomarker in the diagnosis of early-mid stage and advanced CRC compared with existing biomarkers CA199 and CEA.