In studies of heart failure, Andreas Oberbach [30] found that the levels of several proteins (including alpha-2-Macroglobulin (A2M), integrin alpha-2 (ITGA2), and amyloid-beta A4 precursor protein-binding family A member 1 (APBA1)) varied, as well as bacterial proteins were detected in HDL in chronic heart failure patients. The gene discussed is A2M; the disease is congestive heart failure.