Discovering the proteomic changes in the HDL subclasses seems very effective for evaluating the function of the HDL subclasses; for example, Gordon, S. M. [41] discovered that rosuvastatin treatment resulted in increase of SERPINA1 in SEC-isolated L-HDL particles and enhanced HDL anti-inflammatory functionality, and Dr. Heinecke [11] found that diabetes impaired cholesterol efflux to S-HDL particles through the alteration of APOC2 and SERPINA1 levels in S-HDL. The gene discussed is SERPINA1; the disease is diabetes mellitus.