In a xenograft model, a possible profile of brain metastasis marker HER2 + /EGFR + /Heparanase (HPSE) + /Notch1 + in Epithelial Cell Adhesion Molecule (EpCAM)-circulating tumor cells (CTCs) was found to be highly invasive and able to spread to the brain and lungs [45]. Here, EPCAM is linked to neoplasm.