What’s more, other members of KLF family have been reported to significantly regulate the fibrotic process by transcriptionally regulating TGF-β expression, such as KLF4, KLF5, KLF6, and KLF15 [47–50], which indicates the great potential of KLF2 as a key gene involved in HCC fibrosis. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.