The most common symptoms of IgE-mediated wheat allergy, which usually appear within minutes to hours after exposure, involve gastrointestinal symptoms (nausea, abdominal pain, vomiting, diarrhea), skin (pruritus, eczema, redness), respiratory (rhinitis, asthma), circulatory (flushing, angioedema), and cerebral (thought disturbance, headache, dizziness)1,6,8. This evidence concerns the gene IGHE and wheat allergic reaction.