The most common symptoms of IgE-mediated wheat allergy, which usually appear within minutes to hours after exposure, involve gastrointestinal symptoms (nausea, abdominal pain, vomiting, diarrhea), skin (pruritus, eczema, redness), respiratory (rhinitis, asthma), circulatory (flushing, angioedema), and cerebral (thought disturbance, headache, dizziness)1,6,8. The gene discussed is IGHE; the disease is asthma.