INS and Hyperglycemia: Interestingly, low-dose streptozotocin (STZ), which depletes insulin, causing hyperglycaemia due to β-cell destruction (Extended Data Fig. 2a–c), failed to block lipid-driven mTORC1 (P-S6Ser235/236), mTORC2 (P-AKTSer473) and AKT (P-AKTThr308) activation (Extended Data Fig. 2d–g).