ERBB2 and pachyonychia congenita: The therapeutic efficacy of HER2-GFP-CAR-PMs (HG-CAR-PMs) and HER2-FcεR1γ-CAR-PMs (HF-CAR-PMs) against GC cells were evaluated by constructing the in vitro three-dimensional (3D) GC cell spheres model and the in vivo mouse model of PC.