The dhx9 gene locus at 1q25 is frequently mutated in breast and prostate neoplasms [25, 26] and RHA overexpression was dubbed a biomarker of malignancies including lung and ovarian cancer [26], hepatocellular carcinoma [27], glioblastoma [28], chemo resistant leukemia [29], and osteosarcoma exhibiting high metastatic ability [30, 31]. The gene discussed is DHX9; the disease is osteosarcoma.