Finally, treatment with PD, either alone or in combination with ATO, also caused decreased Y360 phosphorylation of BCR::ABL1 in all the samples analyzed and Y177 residue in 6 out of the 11 samples analyzed (except for K562-R, LAMA84-R, ARR230-R, SUP-B15 and ALL#2) (Fig. 4A and Supplementary Fig. 6). Here, ABL1 is linked to acute lymphoblastic leukemia.