The purpose of this work is to analyze and characterize the local and systemic participation of immunologic response in an experimental model of BD, though evaluation of TNF-α, IL-1β, IL-6, IL-10, the quantification of macrophages, NF-κB activity in hepatic tissue, liver allogenicity, and, evaluate liver biochemistry parameters by determining plasma levels of AST, ALT, LDH and ALF in patient with and without BD. This evidence concerns the gene IL1B and Behcet disease.