METTL3 and neoplasm: However, this phenotype appeared to be at least in part dependent on the specificities of the experimental system, since another study found improved immunosuppression of tumor-infiltrating myeloid cells lacking Mettl315, while targeting Mettl3 using small molecule inhibitors had a strong anti-tumor activity in acute myeloid leukemia, leading to increased cell differentiation and apoptosis16.