BACE1 and neoplasm: We next used multivariable models to assess the additional prognostic information provided by the proteomic clusterships (ASP1 and ASP2) (Fig. 5b), RNA-seq clusterships (Fig. S7A), or aetiology (primary or secondary AS) compared to the use of baseline clinico-pathological variables (tumour grade, size and depth) alone (Fig. 5e).