We also observed the downregulation of NDRG1 and upregulation of LMF1 in CC-WT cells (Fig. 5e and f), which have both been found to be independently associated with a poorer prognosis in CRC [40, 41] suggesting that wildtype cells neighbouring FBXW7−/− cells have a worse prognosis compared with wildtype cells by its own. The gene discussed is LMF1; the disease is colorectal carcinoma.