A significant increase of H2AX phosphorylation was observed 24 h after oxaliplatin treatment (Fig. 2G, H), whereas a sharp reduction of 53BP1 foci number was evident in both HCT116 and CRC-SC#1 KDM1A-silenced cells, compared with controls, at 8- and 24-h after oxaliplatin treatment (Fig. 2I, J). Here, TP53BP1 is linked to colorectal carcinoma.