ARL1 and neoplasm: Notably, KDM1A-silenced CRC-SCs were significantly enriched in tumor suppressors involved in the regulation of actin filament depolymerization and polymerization processes as well as cell and anchoring junctions, including ADP-ribosylation factor-like protein 1 (ARL1), reported to be involved in cell polarity preservation [53], and galectin 1 and 4, associated with intestinal cells secretion and brush borders maintenance [54, 55].