Likewise, proteomic analysis revealed a significant downmodulation of proteins involved in cell migration and interaction with the extracellular environment, including thromboxane A2 synthase1 (TBXAS1), usually associated with anchorage-independent growth and invasion [58]; integrin 6 (ITGA6) linked with CRC-SCs self-renewal maintenance [59]; the type I transmembrane protein chondroitin sulfate proteoglycan 4 (CSPG4) reported to potentiate glioblastoma cancer cells proliferation, migration, and adhesion [60]. The gene discussed is CSPG4; the disease is colorectal carcinoma.