Next, we focus on the top-ranked differential genes in the three gene sets, and significantly correlated with the expression of LIMD1-AS1 in the TCGA and CGGA database (Fig. 9C, Supplementary Fig. 6A–J), indicating LIMD1-AS1 and interferon signaling were usually co-expressed in glioma. Here, LIMD1 is linked to central nervous system cancer.