TP53 and early-onset autosomal dominant Alzheimer disease: In parallel, the KEGG enrichment revealed the relationship between these genes and human papillomavirus infection, ubiquitin-mediated proteolysis, pathways of neurodegeneration-multiple diseases, the p53 signaling pathway and Alzheimer’s disease (Supplementary Table S6), consistent with what has been reported in the literature [16, 20–23].