Both genes are located at critical regions of imprinting disorders that may be associated with CPP (MKRN3 at chromosome 15q11-q13 of Prader-Willi syndrome and DLK1 at chromosome 14q32.2 of Temple syndrome) (6). The gene discussed is MKRN3; the disease is motor developmental delay due to 14q32.2 paternally expressed gene defect.