In this issue of Kindey360, Kuno and colleagues identified albumin clearance (CALB) as a novel predictor of relapse of proteinuria in adult patients with steroid-sensitive MCNS.7 This retrospective cohort study included 103 adult patients with nephrotic syndrome who were diagnosed with MCNS using kidney biopsy between 2010 and 2020 in four hospitals in Japan and achieved remission of proteinuria after initiating corticosteroid therapy. This evidence concerns the gene ALB and lipoid nephrosis.