PINK1 and Parkinson disease: Indeed, targeted functional screening for PINK1-dependent mitophagy initiation modifiers among PD GWAS candidate genes has recently identified KAT8 and KANSL1 of the nonspecific lethal epigenetic remodeling complex [7], and it will be interesting to understand whether genes at other idiopathic PD risk loci are also involved in the mitophagy process.