PRKN and Parkinson disease: Other strategies aiming to enhance mitophagy in a PINK1–Parkin-independent manner are also being explored; however, the described cellular specificity of PINK1–Parkin-dependent activity at damaged mitochondria, and particularly that of PINK1 as the upstream mitochondrial damage sensor [3], could make these targets the most efficacious and safest routes for clinical intervention in PD.