Among them, 6 genes (NPTX1, AUTS2, RPS6KA2, KAT2B, MYO5A and HMG20B) were simultaneously downregulated in the melanoma samples compared with the noncancerous samples in GSE31909 and GSE35388 microarray data (Fig 5B and 5C). This evidence concerns the gene NPTX1 and melanoma.