Interestingly, MUC4 rs1104760 recessive model showed a strong effect on increased mortality of colon cancer at both 3 and 5 years (3 years, adjusted HR = 3.703, 95% CI: 1.280–0.712, P = 0.016; 5 years, adjusted HR = 3.474, 95% CI: 1.244–9.706, P = 0.018) but showed no association with the risk of rectal cancer. The gene discussed is MUC4; the disease is rectal cancer.