Conversely, FOS and SOCS3 were both downregulated in vaginal melanoma and were identified as validated gene targets of two or more upregulated miRs (miR-17-5p, miR-181a-5p, and miR-20a-5p for FOS, and miR-19b-3p and miR-20a-5p for SOCS3, Fig 5B). The gene discussed is SOCS3; the disease is vaginal melanoma.