Of these, the most significantly enriched pathway was “Kinetochore metaphase signaling pathway” (p = 5.38E-05) which incorporates 9 genes with significantly increased mRNA expression in vulvar melanoma (AURKB, BIRC5, BUB1, BUB1B, CCNB1, CDK1, KIF2C, NUF2, and PLK1). This evidence concerns the gene CCNB1 and vulvar melanoma.