In contrast, eIF4A suppression had little to no effect on the expression of other targets, including cyclin B1, cyclin E, YAP, and oncogenic signaling molecules, such as RAS, PI3K, AKT, ERK, MET, and HER2, suggesting that these targets are not controlled by eIF4A in these NSCLC cells (Figure 5A, heatmap of protein expression; Supplemental Figure 3, Western blots). This evidence concerns the gene AKT1 and non-small cell lung carcinoma.