In contrast, eIF4A suppression had little to no effect on the expression of other targets, including cyclin B1, cyclin E, YAP, and oncogenic signaling molecules, such as RAS, PI3K, AKT, ERK, MET, and HER2, suggesting that these targets are not controlled by eIF4A in these NSCLC cells (Figure 5A, heatmap of protein expression; Supplemental Figure 3, Western blots). The gene discussed is CCNE1; the disease is non-small cell lung carcinoma.