Finally, because altering diet may affect the course of disease in transgenic ALS mouse models (46), we raised an independent cohort of Thy1-TDPTg/Tg animals on a high-fat, gel-food diet and observed a similar improvement in motor behavior with a greater extension of survival with P1 Nlk ASO injections (Supplemental Figure 10). The gene discussed is NLK; the disease is amyotrophic lateral sclerosis.