TARDBP and amyotrophic lateral sclerosis: Although human genetics studies have revealed ALS-causing mutations in numerous genes that converge on the ALP (48, 49), the animals used in the present study have not been reported to display overt impairments in autophagy/lysosome function, likely due to the aggressive disease progression in these models that contributes to premature lethality prior to robust lysosomal dysfunction that may eventually be induced by aberrant TDP-43 aggregation (50).