HSD3B2 is related to the etiology of hypospadias and was reported as causative or contributory to hypospadias in earlier studies (Codner et al., 2004a; Wang et al., 2007; Rabbani et al., 2012) due to its role in the synthesis of endocrinal factors that regulate fetal urogenital system development (van der Zanden et al., 2012). Here, HSD3B2 is linked to hypospadias.