observed that in ESCC cells, circDOPEY2 functions as a protein scaffold to enhance CPEB4 ubiquitination and degradation in a TRIM25-dependent manner, increasing cisplatin-induced apoptosis by inhibiting CPEB4’s promotion of Mcl-1 translation and reducing cisplatin resistance (111). This evidence concerns the gene CPEB4 and esophageal squamous cell carcinoma.