PTPN11 and chronic myelogenous leukemia, BCR-ABL1 positive: In CML, PTPN11 variant (NM_002834.5:c.1529A>T) p.(Gln510Leu), which is also a known variant in Noonan-syndrome (RCV001261023.1), was detected in a patient suffering from blast crisis after 10 years of TKI treatment (40).