VEGFA and gastric cancer: The VEGF in the serum of patients with GC mainly comes from the primary lesion, while VEGF also recruits effector cells such as endothelial cells, hematopoietic stem cells, osteoblasts and osteoclasts in the bone marrow to the site of neovascularization, thereby forming the embryonic form of new blood vessels, increasing VEGF expression in peripheral blood (54).