VEGF is closely related to nitric oxide (NO) and can reduce endothelial nitric oxide synthetase (NOS) activity (38), reduce vascular tension to increase microvascular permeability, which is conducive to the extravasation of fibrinogen and other plasma proteins, and become the basis of tumor neovascularization network formation and accelerate tumor hematogenous metastasis (39). The gene discussed is VEGFA; the disease is neoplasm.