In summary, we analyzed and integrated data from 488 COAD and 155 READ patients, 102 cancer cell lines, more than 15,000 immunostainings, and ∼10,000 raw associations between RBPs and cancer genes to unravel new RBPs involved in COAD (NOP56, NAT10, RBM12, and FKBP1A) and READ (EMG1 and CSE1L). This evidence concerns the gene EMG1 and colon adenocarcinoma.