In summary, we analyzed and integrated data from 488 COAD and 155 READ patients, 102 cancer cell lines, more than 15,000 immunostainings, and ∼10,000 raw associations between RBPs and cancer genes to unravel new RBPs involved in COAD (NOP56, NAT10, RBM12, and FKBP1A) and READ (EMG1 and CSE1L). The gene discussed is CSE1L; the disease is cancer.