The five most enriched biological KEGG pathways were 1) the PI3K-Akt signaling pathway (1.66E-18), 2) pathways in cancer (5.36E-17), 3) MAPK signaling pathway (1.38E-15), 4) proteoglycans in cancer (6.64E-13), and 5) AGE-RAGE signaling pathway in diabetic complications (1.22E-12), containing 32, 36, 27, 21, and 16 genes related to pathway enrichment analysis, respectively, and other highly enriched pathways including the relaxin signaling pathway, focal adhesion, rheumatoid arthritis, Chagas disease, and IL-17 signaling pathway. Here, PIK3CA is linked to rheumatoid arthritis.