lncRNA MACC1-AS1 in pancreatic cancer (PC) is also upregulated and associated with bad prognosis (Qi et al., 2019), its KD prevents the metastasis of PC cells by promoting the expression of paired-box gene 8 (PAX8), which is essential in activating NOTCH 1 signaling and enhancing cell aerobic glycolysis (Qi et al., 2019). The gene discussed is PAX8; the disease is pachyonychia congenita.