Interestingly, knocking down (KD) of ncRNA-TUG1 and suppressing the miR-455-3p expression leads to decreased activity of adenosine monophosphate–activated protein kinase subunit b2 (AMPKb2), which in turn affects HK2 and reduces the migration and invasion of hepatocellular carcinoma (HCC) cells (Lin et al., 2018b). This evidence concerns the gene HK2 and hepatocellular carcinoma.