HOTAIR and breast cancer: For example, the lncRNA HOX antisense intergenic RNA (HOTAIR), a 2.2-kb gene located in the mammalian HOXC locus on chromosome 12q13.13 (Rinn et al., 2007), has been shown to promote metastasis in breast cancer (BC) by repressing the expression of genes involved in cell adhesion and promoting the expression of genes involved in cell migration and invasion (Abba et al., 2021).