NFKB1 and breast cancer: In response to hypoxia-induced Ca2+ influx, lncRNA calcium-dependent kinase activation (lncRNA CamK-A) activates NF-κB by degrading IκB to upregulate the expressions of IL6, IL8, and VEGF in BCs, promoting angiogenesis and macrophage recruitment in patient-derived BC xenografts (Sang et al., 2018) (Figure 4).