Histone deacetylase 3 is recruited by direct interaction of transforming growth factor β (TGF-β)–induced factor homeobox 2 (TGIF2) in the nucleus with PKM2 and subsequent deacetylation to the E-cadherin promoter, thus suppressing E-cadherin transcription in colon cancer cells and promoting EMT (Hamabe et al., 2014). This evidence concerns the gene CDH1 and colonic neoplasm.