Interestingly, a number of pro-inflammatory cytokines (CXCL6, CXCL10, CXCL12) have been identified to be highly upregulated by RNA sequencing in HUVEC upon TDP-43 KD (Supplementary Table S1), which might also contribute to disease progression in ALS by modulating the inflammatory response. The gene discussed is CXCL12; the disease is amyotrophic lateral sclerosis.