VEGFA and brain edema: In contrast to non-selective therapies, novel targeted therapeutics modulate components of cell-cell signaling pathways implicated in cerebral edema, including Sur1-Trpm4 channel inhibitors, vascular endothelial growth factor-related drugs, ion channel inhibitors, aquaporin blockade agents, and microRNAs (Halstead and Geocadin, 2019; Yao et al., 2020) gC1qR inhibition is a unique mechanism of action as it may attenuate pathologic inflammatory cascades by simultaneously mediating multiple pathways that contribute to cerebral edema.