Targeting ligands associated with nanoparticles represent a novel gC1qR-directed strategy that has been studied in the context of cancer treatment (Paasonen et al., 2016), using a mouse model of MCF10Ca1A breast tumor cells, identified a low molecular weight molecule with affinity for a tumor-homing binding site on gC1qR and attached it to an iron oxide nanoparticle. Here, C1QBP is linked to cancer.