CASP3 and neoplasm: Increase the production of lactate dehydrogenase and ROS; Increase the apoptosis rate; Increase the cytoplasmic expression of PARP, cytochrome c and caspase-3; Reduce the expression of cytochrome c in mitochondria; Prevent DNA repair of tumor cells; Aggravate the cumulative damage of DNA; Increase the production of LDH and ROS.