It has been reported that hydralazine showed a trend toward aggravated AAA (1.59 ± 0.21 vs. 1.38 ± 0.03; hydralazine vs. vehicle) and atherosclerotic lesion areas (3.00 ± 0.40 vs. 1.74 ± 0.50 mm2, hydralazine vs. vehicle, and p = 0.06) in Ang II-infused mice, although the differences were not significant (Cassis et al., 2009). Here, AGT is linked to triple-A syndrome.