PTDSS1 and myocardial infarction: Our observations suggested that (1) the cardiac GPLs profile was markedly changed in post-MI mice, while the plasma GPLs profile was not altered; (2) the PS family is an important contributor to MI injury; (3) downregulation of PSS1 is responsible for decreased PS synthesis in the cardiac tissue of post-MI mice; (4) cardiomyocytes have high expression of PSS1; and (5) anti-apoptotic effects of PSS1 in cardiomyocytes may play a pivotal role in the protection of MI injury.