ADCY7 and major depressive disorder: In addition, they found the upregulation of the ADCY7 transcript in the amygdala by quantitative polymerase chain reaction, confirming that ADCY7 is related to MDD, and found that rs1064448 (one of the SNPs of the ADCY7 haplotype locus), in which T allele carriers had greater left amygdala reactivity than G allele homozygous carriers.