This analysis delineates the possible pathway in the IBD pathogenesis showing the interconnection between gut epithelium damage (I-FABP, L-FABP, TFF-3), reflected by molecules recognizing microbial translocation (MBL, LBP, CD14) and subsequent immune response (IL-18, IL-33) with a central role of TNF-α and MMP-9. This evidence concerns the gene TNF and inflammatory bowel disease.