Since the imbalance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) plays an important role in the remodelation of extracellular matrix of intestinal wall during IBD, Carbon et al. [24] showed that reduced levels of serum TIMP-2 but not TIMP-1, MMP-8, MMP-9 at 14 weeks from baseline predicted good response to anti-TNF-α therapy. This evidence concerns the gene TNF and inflammatory bowel disease.