The LRP1 and the LRP2 receptor are discussed as important modulators in the context of the Alzheimer disease because they contribute to the clearance of amyloid-beta (Aβ) peptide (Shinohara et al., 2017; Cai et al., 2018; Tachibana et al., 2019; Knopman et al., 2021). This evidence concerns the gene LRP1 and Alzheimer disease.