LRP1 and early-onset autosomal dominant Alzheimer disease: The LDL-family of receptors and its member LRP1 have classically been associated with a modulation of lipoprotein metabolism and have been studied for example, with reference to Alzheimer’s disease (Hussain et al., 1999; Jaeger and Pietrzik, 2008; Eggert et al., 2018; Sousa et al., 2023).