Among the GM-related genes that were causally associated with SS, TEC gene encodes a non-receptor protein tyrosine kinase with a pleckstrin homology domain that is involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G protein-coupled receptors, and integrin molecules, key players in the regulation of immune functions, an integral component of T cell signaling, and plays a distinct role in T cell activation (67, 68). This evidence concerns the gene PLEK and synovial sarcoma.