In order to further corroborate the blocking capability of the ACE2-Mb TM in vivo and to test whether or not a local (intranasal) administration could protect against infection, Syrian hamsters were infected with the SARS-CoV-2 Delta VOC either in the presence (Figure 7, treated) or absence (Figure 7, control) of the ACE2-Mb TM. The gene discussed is MB; the disease is infection.