In addition, GCDFP-15 negativity was considerably related to a shorter disease-unfastened survival time in univariate and multivariate analysis (the study by Salinas et al., 2012) additionally reported that the immunohistochemical expression of GCDFP-15 in metastatic breast carcinoma becomes related to breast histological grade and with growing tumor grade; much less expression of GCDFP-15 is observed (24). Here, PIP is linked to neoplasm.