PIP and breast neoplasm: Overall, the results of the present study showed the expression of the GCDFP-15 marker in 33.3% of breast tumors and its expression had a significant relationship with the grade, differentiation, and vascular invasion of the tumor, so its expression is higher in lower grade tumors; while more differentiation and no vascular invasion was observed, so GCDFP-15 can be considered as a marker to determine tumors with good prognosis.