Upon exposition to chemical tumor initiators, PML-null mice develop significantly more tumors than their wild-type counterparts (Wang et al., 1998), particularly in the presence of another activated oncogenic pathway (Haupt et al., 2013; Scaglioni et al., 2006; Trotman et al., 2006; Wolyniec et al., 2012). Here, PML is linked to neoplasm.