PML and leukemia: While the consequences of these PML/TET2 enforced epigenetic changes were not explored, one should note that in APL, two master genes involved in leukemia initiation or progression (DNMT3A and WT1) regulate the status of 5-methylcytosine, similar to TET2 (Cole et al., 2016; Lehmann-Che et al., 2018; Madan et al., 2016; Rampal et al., 2014; Wang et al., 2015; Zhao et al., 2019).