Of the 52 338 patients with RA in the OPAL data set, 842 eligible b/tsDMARD-naive patients who were new starters of ADA (n = 569; 387 [68.0%] female; 175 [30.8%] male; median age, 56 years [IQR, 47-66 years]) or TOF (n = 273; 201 [73.6%] female; 72 [26.4%] male; median age, 59 years [IQR, 51-68 years]) were identified (Figure 2). This evidence concerns the gene ADA and rheumatoid arthritis.